NFL picks and predictions for Week 10 of the 2025 season, featuring expert picks against the spread, score predictions, and fantasy football insights.
Week 10 NFL Picks Against the Spread
- Broncos (-9.5) over Raiders: The Broncos are riding a six-game win streak and have been dominant at home, while the Raiders have struggled all season and are likely to be outmatched.
- Colts (-6.5) over Falcons: Indianapolis is favored in their international matchup in Berlin, with the Falcons struggling to find consistency this year.
- Bills (-9.5) over Dolphins: Buffalo is expected to dominate Miami, who have shown inconsistency on both sides of the ball.
- Ravens (-3.5) over Vikings: Baltimore’s strong defense should be enough to overcome Minnesota’s offense.
- Patriots (+2.5) vs. Buccaneers: New England is coming off a six-game win streak but faces a tough Tampa Bay team at home; the spread favors the Bucs.
- Saints (+5.5) vs. Panthers: Carolina is favored, but New Orleans has shown flashes of potential and could keep it close.
- Texans (+1.5) over Jaguars: Houston’s defense is among the league’s best, and Jacksonville’s offense has struggled, especially with Trevor Lawrence’s recent form.
- Bears (-4.5) over Giants: Chicago has been surging, while the Giants have faltered and lost key players at the trade deadline.
- Browns (-2.5) over Jets: Cleveland’s defense is strong, and the Jets have traded away key players, weakening their roster.
- Seahawks (-6.5) over Cardinals: Seattle is favored at home, with Rashid Shaheed expected to make an impact in his debut.
- Lions (-7.5) over Commanders: Detroit is seeking revenge after last year’s playoff loss and is favored to win decisively.
- Rams (-4.5) over 49ers: Los Angeles is favored in a key NFC West matchup.
- Steelers (+3) vs. Chargers: Pittsburgh is the underdog but could pull off an upset in Los Angeles.
- Packers (-2.5) over Eagles: Green Bay is favored in a Monday Night Football rematch at Lambeau Field.
Kyle Long and Pete Prisco in CBS Sports with their picks and best bets for EVERY Week 10 game of the NFL season.
Score Predictions for Key Matchups
- Broncos 27, Raiders 17: Denver’s home dominance and strong defense should lead to a comfortable win.
- Colts 31, Falcons 15: Indianapolis is expected to control the game in Berlin.
- Bills 34, Dolphins 20: Buffalo’s offense should overpower Miami.
- Ravens 24, Vikings 17: Baltimore’s defense will be the difference.
- Buccaneers 27, Patriots 24: Tampa Bay’s turnover advantage and home-field edge could be decisive.
- Texans 23, Jaguars 20: Houston’s defense will stifle Jacksonville’s offense.
- Bears 24, Giants 17: Chicago’s recent form gives them the edge.
- Browns 21, Jets 17: Cleveland’s defense will hold off a depleted Jets squad.
- Seahawks 30, Cardinals 20: Seattle’s offense, led by new additions, should dominate.
- Lions 31, Commanders 24: Detroit’s revenge motive and strong offense should prevail.
- Rams 27, 49ers 24: A close NFC West battle, with Los Angeles edging out San Francisco.
- Steelers 24, Chargers 21: Pittsburgh could pull off an upset on the road.
- Packers 27, Eagles 24: Green Bay’s home-field advantage and strong defense will be key.
Fantasy Football Bold Predictions
- Kenneth Walker III: Rushes for 100+ yards against the Jets’ depleted defense.
- David Montgomery: Breaks out with a big game for the Bears.
- Stefon Diggs: Has a big receiving day against the Dolphins.
- Jauan Jennings: Scores a touchdown in the 49ers’ offense.
- Dalton Kincaid: Makes a significant impact for the Bills.
Key Notes and Upsets
- The Broncos are a strong favorite at home, but the Raiders could keep it close early.
- The Colts’ defense, now featuring Sauce Gardner, is expected to dominate the Falcons.
- The Patriots’ six-game win streak could be tested by the Buccaneers, who are coming off a bye.
- The Texans’ defense is among the league’s best, making them a sneaky pick against the Jaguars.
- The Packers are favored over the Eagles in a highly anticipated Monday Night Football matchup.
This week’s slate features several intriguing matchups, with playoff implications and fantasy football implications for every game. Stay tuned for live updates and in-depth analysis as the actionupdates and in-depth analysis as the action unfolds.